Assay Detail
Binding
CHEMBL939351
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of myosin light chain kinase
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Myosin light chain kinase, smooth muscle (CHEMBL2428) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.21 | 5.44 |
| Ki | 2 | 5.28 | 5.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38380 | FASUDIL | 3.0 | 1 | 5.44 |
| CHEMBL541401 | — | — | 1 | 5.43 |
| CHEMBL429298 | — | — | 1 | 5.42 |
| CHEMBL219301 | — | — | 1 | 5.13 |
| CHEMBL537897 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38380 | FASUDIL | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL541401 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL429298 | — | Ki | = | 3800.0 | nM | 5.42 |
| CHEMBL219301 | — | Ki | = | 7400.0 | nM | 5.13 |
| CHEMBL537897 | — | IC50 | = | 17800.0 | nM | 4.75 |