Assay Detail

CHEMBL939375

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Functional

Antiproliferative activity against human HeLa cells

ChEMBL ↗

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Target

HeLa (CHEMBL399) ↗

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Primary target HeLa

CHEMBL399

Anchored from Assay target.

Protein identity HeLa

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	HeLa
Confidence	1 — Organism
Curated By	Autocuration

Target

HeLa (CHEMBL399) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

Fedorov O, Marsden B, Pogacic V, Rellos P, Müller S, Bullock AN, Schwaller J, Sundström M, Knapp S.
Proc Natl Acad Sci U S A (2007) 104 : 20523 -20528
PubMed 18077363 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	7.46	7.46

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL261720	—	—	1	7.46
CHEMBL262615	HIAZOLIDINEDIONE1	—	1	-

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL261720	—	IC50	=	35.0	nM	7.46
CHEMBL262615	HIAZOLIDINEDIONE1	IC50	<=	25000.0	nM	-