Assay Detail
Binding
CHEMBL939381
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity at MLCK
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Myosin light chain kinase, smooth muscle (CHEMBL2428) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 4.78 | 5.00 |
| IC50 | 2 | 4.92 | 4.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL406821 | — | — | 1 | 5.00 |
| CHEMBL69863 | PICEATANNOL | — | 1 | 4.92 |
| CHEMBL104264 | — | — | 1 | 4.55 |
| CHEMBL143054 | — | — | 1 | - |
| CHEMBL265470 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL406821 | — | Ki | = | 10100.0 | nM | 5.00 |
| CHEMBL69863 | PICEATANNOL | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL104264 | — | Ki | = | 28300.0 | nM | 4.55 |
| CHEMBL143054 | — | Ki | = | 150000.0 | nM | - |
| CHEMBL265470 | — | IC50 | = | 10.0 | ug.mL-1 | - |