Assay Detail
Binding
CHEMBL939830
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG expressed in HEK cells by competitive radioligand binding assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Allosteric inhibitors of Akt1 and Akt2: discovery of [1,2,4]triazolo[3,4-f][1,6]naphthyridines with potent and balanced activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.41 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL508861 | — | — | 1 | 5.70 |
| CHEMBL445464 | — | — | 1 | 5.56 |
| CHEMBL506077 | — | — | 1 | 5.28 |
| CHEMBL499555 | — | — | 1 | 5.27 |
| CHEMBL507130 | — | — | 1 | 5.25 |
| CHEMBL447328 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL508861 | — | IC50 | = | 2018.0 | nM | 5.70 |
| CHEMBL445464 | — | IC50 | = | 2778.0 | nM | 5.56 |
| CHEMBL506077 | — | IC50 | = | 5312.0 | nM | 5.28 |
| CHEMBL499555 | — | IC50 | = | 5319.0 | nM | 5.27 |
| CHEMBL507130 | — | IC50 | = | 5610.0 | nM | 5.25 |
| CHEMBL447328 | — | IC50 | > | 10000.0 | nM | - |