Assay Detail
Binding
CHEMBL939832
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Inhibition of human cloned Akt2 expressed in Drosophila S2 cells by HTRF assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | S2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
RAC-beta serine/threonine-protein kinase (CHEMBL2431) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Allosteric inhibitors of Akt1 and Akt2: discovery of [1,2,4]triazolo[3,4-f][1,6]naphthyridines with potent and balanced activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.85 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL508794 | — | — | 1 | 8.55 |
| CHEMBL506077 | — | — | 1 | 8.17 |
| CHEMBL499555 | — | — | 1 | 8.03 |
| CHEMBL447328 | — | — | 1 | 8.00 |
| CHEMBL508861 | — | — | 1 | 7.98 |
| CHEMBL502854 | — | — | 1 | 7.98 |
| CHEMBL445464 | — | — | 1 | 7.84 |
| CHEMBL509747 | — | — | 1 | 7.62 |
| CHEMBL446779 | — | — | 1 | 7.26 |
| CHEMBL442919 | — | — | 1 | 7.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL508794 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL506077 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL499555 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL447328 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL508861 | — | IC50 | = | 10.5 | nM | 7.98 |
| CHEMBL502854 | — | IC50 | = | 10.4 | nM | 7.98 |
| CHEMBL445464 | — | IC50 | = | 14.6 | nM | 7.84 |
| CHEMBL509747 | — | IC50 | = | 24.1 | nM | 7.62 |
| CHEMBL446779 | — | IC50 | = | 55.1 | nM | 7.26 |
| CHEMBL442919 | — | IC50 | = | 77.9 | nM | 7.11 |