Assay Detail
Binding
CHEMBL939834
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Inhibition of Akt2 by cell based assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
RAC-beta serine/threonine-protein kinase (CHEMBL2431) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Allosteric inhibitors of Akt1 and Akt2: discovery of [1,2,4]triazolo[3,4-f][1,6]naphthyridines with potent and balanced activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.76 | 7.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL447328 | — | — | 1 | 7.39 |
| CHEMBL499555 | — | — | 1 | 7.32 |
| CHEMBL508794 | — | — | 1 | 7.13 |
| CHEMBL502854 | — | — | 1 | 6.97 |
| CHEMBL506077 | — | — | 1 | 6.78 |
| CHEMBL445464 | — | — | 1 | 6.75 |
| CHEMBL442919 | — | — | 1 | 6.60 |
| CHEMBL446779 | — | — | 1 | 6.42 |
| CHEMBL508861 | — | — | 1 | 6.32 |
| CHEMBL509747 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL447328 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL499555 | — | IC50 | = | 47.7 | nM | 7.32 |
| CHEMBL508794 | — | IC50 | = | 74.8 | nM | 7.13 |
| CHEMBL502854 | — | IC50 | = | 107.6 | nM | 6.97 |
| CHEMBL506077 | — | IC50 | = | 167.7 | nM | 6.78 |
| CHEMBL445464 | — | IC50 | = | 176.5 | nM | 6.75 |
| CHEMBL442919 | — | IC50 | = | 251.4 | nM | 6.60 |
| CHEMBL446779 | — | IC50 | = | 376.1 | nM | 6.42 |
| CHEMBL508861 | — | IC50 | = | 483.3 | nM | 6.32 |
| CHEMBL509747 | — | IC50 | = | 1213.0 | nM | 5.92 |