Assay Detail
Binding
CHEMBL939892
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 5-lipoxygenase in A-23817-challenged human whole blood assessed as 5-HETE formation after 10 mins by intact cell based assay
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.80 | 5.80 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL490461 | — | — | 2 | 5.80 |
| CHEMBL519150 | — | — | 2 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL490461 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL519150 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL490461 | — | Activity | - | — | - | |
| CHEMBL519150 | — | Activity | - | — | - |