Assay Detail
Binding
CHEMBL939932
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Inhibition of human JNK1 by radiometric assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 7.07 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL260429 | — | — | 1 | 8.48 |
| CHEMBL261014 | — | — | 1 | 8.04 |
| CHEMBL261841 | — | — | 1 | 7.92 |
| CHEMBL259916 | — | — | 1 | 7.85 |
| CHEMBL407960 | — | — | 1 | 7.80 |
| CHEMBL259706 | — | — | 1 | 7.70 |
| CHEMBL259092 | — | — | 1 | 7.68 |
| CHEMBL259812 | — | — | 1 | 7.55 |
| CHEMBL259060 | — | — | 1 | 7.52 |
| CHEMBL410707 | — | — | 1 | 7.38 |
| CHEMBL407956 | — | — | 1 | 7.37 |
| CHEMBL261186 | — | — | 1 | 7.32 |
| CHEMBL259404 | — | — | 1 | 7.23 |
| CHEMBL411635 | — | — | 1 | 7.21 |
| CHEMBL258883 | — | — | 1 | 7.20 |
| CHEMBL258703 | — | — | 1 | 7.10 |
| CHEMBL258676 | — | — | 1 | 7.07 |
| CHEMBL260126 | — | — | 1 | 7.05 |
| CHEMBL410318 | — | — | 1 | 7.02 |
| CHEMBL409936 | — | — | 1 | 7.00 |
| CHEMBL1725279 | SP-600125 | — | 1 | 6.96 |
| CHEMBL408224 | — | — | 1 | 6.85 |
| CHEMBL191384 | — | — | 1 | 6.82 |
| CHEMBL409429 | — | — | 1 | 6.72 |
| CHEMBL259934 | — | — | 1 | 6.35 |
| CHEMBL259544 | — | — | 1 | 6.07 |
| CHEMBL258457 | — | — | 1 | 5.96 |
| CHEMBL406971 | — | — | 1 | 5.85 |
| CHEMBL261086 | — | — | 1 | 5.82 |
| CHEMBL259406 | — | — | 1 | 5.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL260429 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL261014 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL261841 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL259916 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL407960 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL259706 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL259092 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL259812 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL259060 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL410707 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL407956 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL261186 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL259404 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL411635 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL258883 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL258703 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL258676 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL260126 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL410318 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL409936 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1725279 | SP-600125 | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL408224 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL191384 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL409429 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL259934 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL259544 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL258457 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL406971 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL261086 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL259406 | — | IC50 | = | 8800.0 | nM | 5.06 |