Assay Detail
Binding
CHEMBL940155
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to Pyrococcus horikoshii sodium-coupled aspartate transporter L130W mutant fluorescence-based assay in presence of NaCl
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Pyrococcus horikoshii |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Glutamate transporter homolog (CHEMBL4296295) ↗| Type | SINGLE PROTEIN |
| Organism | Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 /NBRC 100139 / OT-3) |
Publication
Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 8.50 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL274323 | ASPARTIC ACID | 3.0 | 1 | 9.00 |
| CHEMBL29757 | D-ASPARTATE | 2.0 | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL274323 | ASPARTIC ACID | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL29757 | D-ASPARTATE | Kd | = | 10.0 | nM | 8.00 |