Assay Detail
Binding
CHEMBL940168
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Inhibition of CaM-KKbeta
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Calcium/calmodulin-dependent protein kinase kinase 2 (CHEMBL5284) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.05 | 8.74 |
| IC50 | 2 | 6.70 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL416056 | — | — | 1 | 8.74 |
| CHEMBL319620 | LAVENDUSTIN C | — | 1 | 6.70 |
| CHEMBL143054 | — | — | 1 | 4.89 |
| CHEMBL104264 | — | — | 1 | 4.53 |
| CHEMBL265470 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL416056 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL319620 | LAVENDUSTIN C | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL143054 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL104264 | — | Ki | = | 29700.0 | nM | 4.53 |
| CHEMBL265470 | — | IC50 | = | 0.04 | ug.mL-1 | - |