Assay Detail
Binding
CHEMBL940369
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Inhibition of human HDAC1 expressed in mammalian cells
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 7.59 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL513250 | — | — | 1 | 8.22 |
| CHEMBL486152 | — | — | 1 | 8.15 |
| CHEMBL486770 | — | — | 1 | 8.10 |
| CHEMBL471399 | — | — | 1 | 8.10 |
| CHEMBL470582 | — | — | 1 | 8.10 |
| CHEMBL513568 | — | — | 1 | 8.10 |
| CHEMBL471414 | — | — | 1 | 8.05 |
| CHEMBL511797 | — | — | 1 | 8.00 |
| CHEMBL470791 | — | — | 1 | 7.96 |
| CHEMBL471824 | — | — | 1 | 7.96 |
| CHEMBL469950 | — | — | 1 | 7.96 |
| CHEMBL472442 | — | — | 1 | 7.92 |
| CHEMBL511984 | — | — | 1 | 7.89 |
| CHEMBL470147 | — | — | 1 | 7.89 |
| CHEMBL471220 | — | — | 1 | 7.89 |
| CHEMBL470581 | — | — | 1 | 7.85 |
| CHEMBL513027 | — | — | 1 | 7.80 |
| CHEMBL471219 | — | — | 1 | 7.77 |
| CHEMBL472261 | — | — | 1 | 7.77 |
| CHEMBL472251 | — | — | 1 | 7.75 |
| CHEMBL469514 | — | — | 1 | 7.68 |
| CHEMBL472252 | — | — | 1 | 7.66 |
| CHEMBL472443 | — | — | 1 | 7.64 |
| CHEMBL471400 | — | — | 1 | 7.64 |
| CHEMBL521193 | — | — | 1 | 7.57 |
| CHEMBL470798 | — | — | 1 | 7.55 |
| CHEMBL470148 | — | — | 1 | 7.54 |
| CHEMBL470156 | — | — | 1 | 7.44 |
| CHEMBL487346 | — | — | 1 | 7.41 |
| CHEMBL255805 | — | — | 1 | 7.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL513250 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL486152 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL471399 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL470582 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL513568 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL486770 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL471414 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL511797 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL470791 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL471824 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL469950 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL472442 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL511984 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL470147 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL471220 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL470581 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL513027 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL471219 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL472261 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL472251 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL469514 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL472252 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL472443 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL471400 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL521193 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL470798 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL470148 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL470156 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL487346 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL255805 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL269935 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL256440 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL236902 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL486738 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL486737 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL520050 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL499776 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL511625 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL236678 | — | IC50 | = | 2630.0 | nM | 5.58 |