Assay Detail
Binding
CHEMBL940370
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Inhibition of human HDAC2 expressed in mammalian cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.54 | 7.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL513568 | — | — | 1 | 7.36 |
| CHEMBL511797 | — | — | 1 | 7.15 |
| CHEMBL471824 | — | — | 1 | 6.96 |
| CHEMBL269935 | — | — | 1 | 6.70 |
| CHEMBL236902 | — | — | 1 | 6.51 |
| CHEMBL256440 | — | — | 1 | 6.41 |
| CHEMBL255805 | — | — | 1 | 6.05 |
| CHEMBL236678 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL513568 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL511797 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL471824 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL269935 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL236902 | — | IC50 | = | 308.0 | nM | 6.51 |
| CHEMBL256440 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL255805 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL236678 | — | IC50 | = | 6980.0 | nM | 5.16 |