Assay Detail
Binding
CHEMBL940414
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Inhibition of full length HCV NS3/4A protease
19
Total Activities
19
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of novel, potent and bioavailable proline-urea based macrocyclic HCV NS3/4A protease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 9.36 | 10.30 |
| IC50 | 3 | 7.39 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL505440 | — | — | 1 | 10.30 |
| CHEMBL489267 | — | — | 1 | 10.00 |
| CHEMBL444708 | — | — | 1 | 10.00 |
| CHEMBL506378 | — | — | 1 | 10.00 |
| CHEMBL501670 | — | — | 1 | 9.70 |
| CHEMBL506515 | — | — | 1 | 9.70 |
| CHEMBL470606 | — | — | 1 | 9.62 |
| CHEMBL443727 | — | — | 1 | 9.52 |
| CHEMBL449844 | — | — | 1 | 9.46 |
| CHEMBL452420 | — | — | 1 | 9.40 |
| CHEMBL498839 | — | — | 1 | 9.35 |
| CHEMBL500009 | — | — | 1 | 9.30 |
| CHEMBL510496 | — | — | 1 | 8.82 |
| CHEMBL503785 | — | — | 1 | 8.62 |
| CHEMBL1163007 | — | — | 1 | 8.00 |
| CHEMBL443512 | — | — | 1 | 8.00 |
| CHEMBL295844 | — | — | 1 | 7.96 |
| CHEMBL501893 | — | — | 1 | 7.92 |
| CHEMBL409025 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL505440 | — | Ki | = | 0.05 | nM | 10.30 |
| CHEMBL489267 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL444708 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL506378 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL501670 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL506515 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL470606 | — | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL443727 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL449844 | — | Ki | = | 0.35 | nM | 9.46 |
| CHEMBL452420 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL498839 | — | Ki | = | 0.45 | nM | 9.35 |
| CHEMBL500009 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL510496 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL503785 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL1163007 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL443512 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL295844 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL501893 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL409025 | — | IC50 | = | 600.0 | nM | 6.22 |