Assay Detail
Functional
CHEMBL940416
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Antiviral activity against HCV infected in human Huh7 cells after 48 hrs by luciferase based replicon assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel, potent and bioavailable proline-urea based macrocyclic HCV NS3/4A protease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 7.48 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL505440 | — | — | 1 | 8.77 |
| CHEMBL444708 | — | — | 1 | 8.66 |
| CHEMBL489267 | — | — | 1 | 8.40 |
| CHEMBL506378 | — | — | 1 | 8.35 |
| CHEMBL506515 | — | — | 1 | 8.30 |
| CHEMBL500009 | — | — | 1 | 8.30 |
| CHEMBL501670 | — | — | 1 | 8.17 |
| CHEMBL443727 | — | — | 1 | 7.96 |
| CHEMBL510496 | — | — | 1 | 7.85 |
| CHEMBL470606 | — | — | 1 | 7.82 |
| CHEMBL498839 | — | — | 1 | 7.58 |
| CHEMBL452420 | — | — | 1 | 7.36 |
| CHEMBL449844 | — | — | 1 | 7.21 |
| CHEMBL295844 | — | — | 1 | 7.11 |
| CHEMBL504551 | — | — | 1 | 7.01 |
| CHEMBL503785 | — | — | 1 | 6.34 |
| CHEMBL501893 | — | — | 1 | 6.16 |
| CHEMBL443512 | — | — | 1 | 5.35 |
| CHEMBL1163007 | — | — | 1 | 5.35 |
| CHEMBL409025 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL505440 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL444708 | — | EC50 | = | 2.2 | nM | 8.66 |
| CHEMBL489267 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL506378 | — | EC50 | = | 4.5 | nM | 8.35 |
| CHEMBL506515 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL500009 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL501670 | — | EC50 | = | 6.8 | nM | 8.17 |
| CHEMBL443727 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL510496 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL470606 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL498839 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL452420 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL449844 | — | EC50 | = | 62.0 | nM | 7.21 |
| CHEMBL295844 | — | EC50 | = | 77.0 | nM | 7.11 |
| CHEMBL504551 | — | EC50 | = | 98.0 | nM | 7.01 |
| CHEMBL503785 | — | EC50 | = | 460.0 | nM | 6.34 |
| CHEMBL501893 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL443512 | — | EC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL1163007 | — | EC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL409025 | — | EC50 | > | 10000.0 | nM | - |