Assay Detail
Binding
CHEMBL940424
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Inhibition of 5LOX
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Characterization of novel furan compounds on the basis of their radical scavenging activity and cytoprotective effects against glutamate- and lipopolysaccharide-induced insults.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.85 | 6.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | — | 1 | 6.42 |
| CHEMBL456234 | — | — | 1 | 6.28 |
| CHEMBL456235 | — | — | 1 | 5.58 |
| CHEMBL25948 | SHOGAOL | — | 1 | 5.13 |
| CHEMBL402978 | GINGEROL | -1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL456234 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL456235 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL25948 | SHOGAOL | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL402978 | GINGEROL | IC50 | - | — | - |