Assay Detail
Functional
CHEMBL940525
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat RBL2H3 cell degranulation assessed as inhibition of beta-hexosamidase release after 10 mins by microplate reader assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | RBL-2H3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Absolute stereostructures of three new sesquiterpenes from the fruit of Alpinia oxyphylla with inhibitory effects on nitric oxide production and degranulation in RBL-2H3 cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.64 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 5.52 |
| CHEMBL164841 | TECHTOCHRYSIN | — | 1 | 4.31 |
| CHEMBL151 | LUTEOLIN | 2.0 | 1 | 4.09 |
| CHEMBL415324 | TRANILAST | 3.0 | 1 | - |
| CHEMBL1633 | KETOTIFEN FUMARATE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL140 | CURCUMIN | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL164841 | TECHTOCHRYSIN | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL151 | LUTEOLIN | IC50 | = | 82000.0 | nM | 4.09 |
| CHEMBL415324 | TRANILAST | IC50 | = | 490000.0 | nM | - |
| CHEMBL1633 | KETOTIFEN FUMARATE | IC50 | = | 220000.0 | nM | - |