Assay Detail
Binding
CHEMBL940557
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Binding affinity to exonuclase deficient HSV1 DNA polymerase UL42 D368A mutant
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human alphaherpesvirus 1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Enzymatic therapeutic index of acyclovir. Viral versus human polymerase gamma specificity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 5.66 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL477486 | DEOXYGUANOSINE TRIPHOSPHATE | — | 1 | 6.10 |
| CHEMBL1673 | ACYCLOVIR TRIPHOSPHATE | -1.0 | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL477486 | DEOXYGUANOSINE TRIPHOSPHATE | Kd | = | 800.0 | nM | 6.10 |
| CHEMBL1673 | ACYCLOVIR TRIPHOSPHATE | Kd | = | 6000.0 | nM | 5.22 |