Assay Detail
Binding
CHEMBL940646
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Inhibition of human recombinant MMP13 by fluorogenic substrate assay
5
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Ranking the selectivity of PubChem screening hits by activity-based protein profiling: MMP13 as a case study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.07 | 6.55 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL475540 | — | — | 1 | 6.55 |
| CHEMBL473326 | — | — | 2 | 6.04 |
| CHEMBL448246 | — | — | 1 | 5.89 |
| CHEMBL500351 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL475540 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL473326 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL448246 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL500351 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL473326 | — | Inhibition | = | 70.0 | % | - |