Assay Detail
Binding
CHEMBL940777
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Inhibition of mushroom tyrosinase
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Agaricus bisporus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
1-(1-Arylethylidene)thiosemicarbazide derivatives: a new class of tyrosinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.01 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL404699 | — | — | 1 | 6.96 |
| CHEMBL401925 | — | — | 1 | 6.85 |
| CHEMBL256865 | — | — | 1 | 6.82 |
| CHEMBL429500 | — | — | 1 | 6.77 |
| CHEMBL256866 | — | — | 1 | 6.57 |
| CHEMBL404884 | — | — | 1 | 6.51 |
| CHEMBL256868 | ACETOPHENONE-THIOSEMICARBAZONE | — | 1 | 6.47 |
| CHEMBL121188 | TROPOLONE | — | 1 | 6.40 |
| CHEMBL401926 | — | — | 1 | 6.38 |
| CHEMBL258261 | — | — | 1 | 6.28 |
| CHEMBL272958 | — | — | 1 | 6.27 |
| CHEMBL256182 | — | — | 1 | 6.24 |
| CHEMBL272957 | — | — | 1 | 6.09 |
| CHEMBL401556 | — | — | 1 | 6.06 |
| CHEMBL258052 | — | — | 1 | 6.00 |
| CHEMBL402139 | — | — | 1 | 4.66 |
| CHEMBL287556 | KOJIC ACID | — | 1 | 4.64 |
| CHEMBL271217 | — | — | 1 | 4.26 |
| CHEMBL256697 | — | — | 1 | 4.00 |
| CHEMBL232202 | ARBUTIN | 2.0 | 1 | - |
| CHEMBL95770 | 4-METHOXYCINNAMIC ACID | — | 1 | - |
| CHEMBL401912 | P-METHOXY-ACETOPHENONE | — | 1 | - |
| CHEMBL257923 | — | — | 1 | - |
| CHEMBL274467 | ACETOPHENONE | — | 1 | - |
| CHEMBL401911 | — | — | 1 | - |
| CHEMBL256250 | THIOSEMICARBAZIDE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL404699 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL401925 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL256865 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL429500 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL256866 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL404884 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL256868 | ACETOPHENONE-THIOSEMICARBAZONE | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL121188 | TROPOLONE | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL401926 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL258261 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL272958 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL256182 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL272957 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL401556 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL258052 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL402139 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL287556 | KOJIC ACID | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL271217 | — | IC50 | = | 55500.0 | nM | 4.26 |
| CHEMBL256697 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL232202 | ARBUTIN | IC50 | = | 10400000.0 | nM | - |
| CHEMBL95770 | 4-METHOXYCINNAMIC ACID | IC50 | = | 410000.0 | nM | - |
| CHEMBL401912 | P-METHOXY-ACETOPHENONE | IC50 | = | 2000000.0 | nM | - |
| CHEMBL257923 | — | IC50 | = | 990000.0 | nM | - |
| CHEMBL274467 | ACETOPHENONE | IC50 | = | 850000.0 | nM | - |
| CHEMBL401911 | — | IC50 | = | 150000.0 | nM | - |
| CHEMBL256250 | THIOSEMICARBAZIDE | IC50 | = | 2000000.0 | nM | - |