Assay Detail
Functional
CHEMBL940863
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at CCR2 in human PBMCs assessed as inhibition of MCP1-induced chemotaxis
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Capped diaminopropionamide-glycine dipeptides are inhibitors of CC chemokine receptor 2 (CCR2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.72 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL247608 | — | — | 1 | 7.41 |
| CHEMBL393267 | — | — | 1 | 7.00 |
| CHEMBL246804 | — | — | 1 | 6.82 |
| CHEMBL392814 | — | — | 1 | 6.72 |
| CHEMBL247455 | — | — | 1 | 6.62 |
| CHEMBL247245 | — | — | 1 | 6.58 |
| CHEMBL398747 | — | — | 1 | 6.50 |
| CHEMBL247621 | — | — | 1 | 6.14 |
| CHEMBL248418 | — | — | 1 | - |
| CHEMBL400196 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL247608 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL393267 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL246804 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL392814 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL247455 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL247245 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL398747 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL247621 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL248418 | — | IC50 | > | 1500.0 | nM | - |
| CHEMBL400196 | — | IC50 | > | 3000.0 | nM | - |