Assay Detail
Binding
CHEMBL940953
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Inhibition of Mycobacterium tuberculosis FabH
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Mycobacterial beta-ketoacyl-[acyl-carrier-protein] synthase III (CHEMBL3640) ↗| Type | SINGLE PROTEIN |
| Organism | Mycobacterium tuberculosis |
Publication
Synthesis and biological evaluation of a C5-biphenyl thiolactomycin library.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 4.69 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL250431 | — | — | 1 | 5.52 |
| CHEMBL399477 | — | — | 1 | 5.40 |
| CHEMBL250429 | — | — | 1 | 5.16 |
| CHEMBL250630 | — | — | 1 | 4.82 |
| CHEMBL249805 | — | — | 1 | 4.27 |
| CHEMBL250819 | — | — | 1 | 4.17 |
| CHEMBL399043 | THIOLACTOMYCIN | — | 1 | 4.12 |
| CHEMBL250824 | — | — | 1 | 4.07 |
| CHEMBL251035 | — | — | 1 | - |
| CHEMBL400501 | — | — | 1 | - |
| CHEMBL250823 | — | — | 1 | - |
| CHEMBL250818 | — | — | 1 | - |
| CHEMBL401380 | — | — | 1 | - |
| CHEMBL249417 | — | — | 1 | - |
| CHEMBL249210 | — | — | 1 | - |
| CHEMBL400279 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL250431 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL399477 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL250429 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL250630 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL249805 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL250819 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL399043 | THIOLACTOMYCIN | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL250824 | — | IC50 | = | 86000.0 | nM | 4.07 |
| CHEMBL251035 | — | IC50 | = | 130000.0 | nM | - |
| CHEMBL400501 | — | IC50 | = | 283000.0 | nM | - |
| CHEMBL250823 | — | IC50 | = | 200000.0 | nM | - |
| CHEMBL250818 | — | IC50 | = | 105000.0 | nM | - |
| CHEMBL401380 | — | IC50 | = | 207000.0 | nM | - |
| CHEMBL249417 | — | IC50 | = | 135000.0 | nM | - |
| CHEMBL249210 | — | IC50 | = | 150000.0 | nM | - |
| CHEMBL400279 | — | IC50 | = | 156000.0 | nM | - |