Assay Detail
Binding
CHEMBL941003
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Inhibition of human PARP1
33
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Rational design of conformationally restricted quinazolinone inhibitors of poly(ADP-ribose)polymerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 7.20 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL401843 | — | — | 1 | 8.10 |
| CHEMBL248648 | — | — | 1 | 8.06 |
| CHEMBL251028 | — | — | 1 | 8.05 |
| CHEMBL250851 | — | — | 1 | 7.92 |
| CHEMBL251030 | — | — | 1 | 7.89 |
| CHEMBL248827 | — | — | 1 | 7.82 |
| CHEMBL399725 | — | — | 1 | 7.80 |
| CHEMBL251027 | — | — | 1 | 7.80 |
| CHEMBL250488 | — | — | 1 | 7.80 |
| CHEMBL250013 | — | — | 1 | 7.80 |
| CHEMBL248826 | — | — | 1 | 7.75 |
| CHEMBL400344 | — | — | 1 | 7.60 |
| CHEMBL400343 | — | — | 1 | 7.60 |
| CHEMBL399637 | — | — | 1 | 7.60 |
| CHEMBL251029 | — | — | 1 | 7.58 |
| CHEMBL250849 | — | — | 1 | 7.52 |
| CHEMBL248649 | — | — | 1 | 7.46 |
| CHEMBL249026 | — | — | 1 | 7.44 |
| CHEMBL249813 | — | — | 1 | 7.34 |
| CHEMBL250850 | — | — | 1 | 7.34 |
| CHEMBL250490 | — | — | 1 | 7.33 |
| CHEMBL250489 | — | — | 1 | 6.99 |
| CHEMBL249220 | — | — | 1 | 6.88 |
| CHEMBL250210 | — | — | 1 | 6.80 |
| CHEMBL250672 | — | — | 1 | 6.59 |
| CHEMBL248834 | — | — | 1 | 6.54 |
| CHEMBL399635 | — | — | 1 | 6.52 |
| CHEMBL246185 | — | — | 2 | 6.36 |
| CHEMBL400581 | — | — | 1 | 6.30 |
| CHEMBL250211 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL401843 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL248648 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL251028 | — | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL250851 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL251030 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL248827 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL399725 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL251027 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL250488 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL250013 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL248826 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL400344 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL400343 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL399637 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL251029 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL250849 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL248649 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL249026 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL249813 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL250850 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL250490 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL250489 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL249220 | — | IC50 | = | 131.0 | nM | 6.88 |
| CHEMBL250210 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL250672 | — | IC50 | = | 257.0 | nM | 6.59 |
| CHEMBL248834 | — | IC50 | = | 286.0 | nM | 6.54 |
| CHEMBL399635 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL246185 | — | IC50 | = | 435.0 | nM | 6.36 |
| CHEMBL400581 | — | IC50 | = | 504.0 | nM | 6.30 |
| CHEMBL246185 | — | IC50 | = | 555.0 | nM | 6.26 |
| CHEMBL250211 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL400299 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL250023 | — | IC50 | = | 8400.0 | nM | 5.08 |