Assay Detail
Binding
CHEMBL941237
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Displacement of [3H]Ro-151788 from benzodiazepine binding site of GABAA alpha-3-beta-2-gamma-2 receptor expressed in HEK293T cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK-293T |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
GABA A receptor alpha-3/beta-2/gamma-2 (CHEMBL2111339) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Structural requirements for eszopiclone and zolpidem binding to the gamma-aminobutyric acid type-A (GABAA) receptor are different.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.96 | 8.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL407 | FLUMAZENIL | 4.0 | 1 | 8.09 |
| CHEMBL1522 | ESZOPICLONE | 4.0 | 1 | 6.79 |
| CHEMBL911 | ZOLPIDEM | 4.0 | 1 | 6.01 |
| CHEMBL6597 | Ro-154513 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL407 | FLUMAZENIL | Ki | = | 8.1 | nM | 8.09 |
| CHEMBL1522 | ESZOPICLONE | Ki | = | 162.0 | nM | 6.79 |
| CHEMBL911 | ZOLPIDEM | Ki | = | 975.0 | nM | 6.01 |
| CHEMBL6597 | Ro-154513 | Ki | - | — | - |