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Assay Detail

CHEMBL941537

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Binding
Inhibition of COX2
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Prostaglandin G/H synthase 2 (CHEMBL230)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and biological evaluation of a library of resveratrol analogues as inhibitors of COX-1, COX-2 and NF-kappaB.
Kang SS, Cuendet M, Endringer DC, Croy VL, Pezzuto JM, Lipton MA.
Bioorg Med Chem (2009) 17 : 1044 -1054
PubMed 18487053 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 5.40 6.33

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL491079 1 6.33
CHEMBL83527 PTEROSTILBENE 2.0 1 6.09
CHEMBL490482 1 6.09
CHEMBL165 RESVERATROL 3.0 1 6.00
CHEMBL474127 1 5.80
CHEMBL489489 1 5.76
CHEMBL482162 1 5.76
CHEMBL491080 1 5.75
CHEMBL470938 1 5.66
CHEMBL468886 1 5.59
CHEMBL513053 1 5.48
CHEMBL210300 1 5.23
CHEMBL491081 1 4.89
CHEMBL471104 1 4.83
CHEMBL474935 1 4.80
CHEMBL471103 1 4.75
CHEMBL291501 RESVERATROL 4'-METHYL ETHER 1 4.71
CHEMBL473518 RHAPONTIGENIN 1 4.67
CHEMBL490673 1 4.50

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL491079 IC50 = 470.0 nM 6.33
CHEMBL83527 PTEROSTILBENE IC50 = 820.0 nM 6.09
CHEMBL490482 IC50 = 820.0 nM 6.09
CHEMBL165 RESVERATROL IC50 = 990.0 nM 6.00
CHEMBL474127 IC50 = 1570.0 nM 5.80
CHEMBL489489 IC50 = 1740.0 nM 5.76
CHEMBL482162 IC50 = 1740.0 nM 5.76
CHEMBL491080 IC50 = 1780.0 nM 5.75
CHEMBL470938 IC50 = 2200.0 nM 5.66
CHEMBL468886 IC50 = 2540.0 nM 5.59
CHEMBL513053 IC50 = 3300.0 nM 5.48
CHEMBL210300 IC50 = 5940.0 nM 5.23
CHEMBL491081 IC50 = 12800.0 nM 4.89
CHEMBL471104 IC50 = 14800.0 nM 4.83
CHEMBL474935 IC50 = 16000.0 nM 4.80
CHEMBL471103 IC50 = 17700.0 nM 4.75
CHEMBL291501 RESVERATROL 4'-METHYL ETHER IC50 = 19600.0 nM 4.71
CHEMBL473518 RHAPONTIGENIN IC50 = 21300.0 nM 4.67
CHEMBL490673 IC50 = 31600.0 nM 4.50