Assay Detail
Binding
CHEMBL941563
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Inhibition of PLK1 expressed in baculovirus-infected Trichoplusia-ni cells by scintillation proximity assay
54
Total Activities
54
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Trichoplusia-ni |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Serine/threonine-protein kinase PLK1 (CHEMBL3024) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of thiophene inhibitors of polo-like kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 54 | 7.70 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL474028 | — | — | 1 | 8.70 |
| CHEMBL514499 | GW843682X | — | 1 | 8.70 |
| CHEMBL474843 | — | — | 1 | 8.70 |
| CHEMBL474432 | — | — | 1 | 8.70 |
| CHEMBL480545 | — | — | 1 | 8.70 |
| CHEMBL514162 | GW852849X | — | 1 | 8.70 |
| CHEMBL519120 | — | — | 1 | 8.40 |
| CHEMBL474053 | — | — | 1 | 8.30 |
| CHEMBL482151 | — | — | 1 | 8.22 |
| CHEMBL474029 | — | — | 1 | 8.22 |
| CHEMBL474054 | — | — | 1 | 8.10 |
| CHEMBL514968 | — | — | 1 | 8.10 |
| CHEMBL481510 | GW853606X | — | 1 | 8.05 |
| CHEMBL518953 | GSK-1023156A | — | 1 | 7.96 |
| CHEMBL480382 | GSK-312948A | — | 1 | 7.96 |
| CHEMBL474603 | — | — | 1 | 7.92 |
| CHEMBL514826 | — | — | 1 | 7.92 |
| CHEMBL475597 | — | — | 1 | 7.92 |
| CHEMBL475857 | — | — | 1 | 7.92 |
| CHEMBL449608 | — | — | 1 | 7.92 |
| CHEMBL518956 | — | — | 1 | 7.92 |
| CHEMBL514643 | — | — | 1 | 7.89 |
| CHEMBL475763 | — | — | 1 | 7.85 |
| CHEMBL508763 | — | — | 1 | 7.85 |
| CHEMBL481491 | — | — | 1 | 7.82 |
| CHEMBL514634 | — | — | 1 | 7.77 |
| CHEMBL520080 | — | — | 1 | 7.77 |
| CHEMBL480383 | — | — | 1 | 7.77 |
| CHEMBL475783 | — | — | 1 | 7.68 |
| CHEMBL481492 | — | — | 1 | 7.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL474028 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL514499 | GW843682X | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL474843 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL474432 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL480545 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL514162 | GW852849X | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL519120 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL474053 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL474029 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL482151 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL474054 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL514968 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL481510 | GW853606X | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL518953 | GSK-1023156A | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL480382 | GSK-312948A | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL474603 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL518956 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL449608 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL475857 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL475597 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL514826 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL514643 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL475763 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL508763 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL481491 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL514634 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL480383 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL520080 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL475783 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL481492 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL445277 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL482349 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL516248 | GW804482X | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL475215 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL475616 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL473630 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL474437 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL481724 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL516362 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL454196 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL520284 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL219899 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL471789 | GSK-1030059A | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL481156 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL514040 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL473629 | GSK-204925A | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL475762 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL519286 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL519289 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL480371 | GW853609X | IC50 | = | 300.0 | nM | 6.52 |