Assay Detail
Functional
CHEMBL941728
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Cytotoxicity against human A549 cells after 72 hrs by sulforhodamine B dye assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Highly efficient antitumor agents of heterocycles containing sulfur atom: linear and angular thiazonaphthalimides against human lung cancer cell in vitro.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.25 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL179856 | — | — | 1 | 9.10 |
| CHEMBL290677 | AZONAFIDE | — | 1 | 8.00 |
| CHEMBL181783 | — | — | 1 | 7.66 |
| CHEMBL391424 | — | — | 1 | 7.51 |
| CHEMBL239615 | — | — | 1 | 7.40 |
| CHEMBL240243 | — | — | 1 | 7.35 |
| CHEMBL240244 | — | — | 1 | 7.06 |
| CHEMBL179971 | — | — | 1 | 6.30 |
| CHEMBL179855 | — | — | 1 | 6.11 |
| CHEMBL428676 | AMONAFIDE | 3.0 | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL179856 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL290677 | AZONAFIDE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL181783 | — | IC50 | = | 21.8 | nM | 7.66 |
| CHEMBL391424 | — | IC50 | = | 30.6 | nM | 7.51 |
| CHEMBL239615 | — | IC50 | = | 39.8 | nM | 7.40 |
| CHEMBL240243 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL240244 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL179971 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL179855 | — | IC50 | = | 772.0 | nM | 6.11 |
| CHEMBL428676 | AMONAFIDE | IC50 | = | 1100.0 | nM | 5.96 |