Assay Detail
Binding
CHEMBL941849
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Displacement of [3H]spiperone from dopamine D2short receptor in CHO cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
In vitro affinities of various halogenated benzamide derivatives as potential radioligands for non-invasive quantification of D(2)-like dopamine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 8.27 | 9.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL241169 | — | — | 1 | 9.13 |
| CHEMBL240106 | — | — | 1 | 9.06 |
| CHEMBL76402 | — | — | 1 | 8.80 |
| CHEMBL392158 | FALLYPRIDE | 3.0 | 1 | 8.68 |
| CHEMBL267723 | IOLOPRIDE | 2.0 | 1 | 8.38 |
| CHEMBL397103 | — | — | 1 | 7.82 |
| CHEMBL397592 | — | — | 1 | 7.57 |
| CHEMBL428561 | — | — | 1 | 7.52 |
| CHEMBL8809 | RACLOPRIDE | 2.0 | 1 | 7.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL241169 | — | Ki | = | 0.74 | nM | 9.13 |
| CHEMBL240106 | — | Ki | = | 0.88 | nM | 9.06 |
| CHEMBL76402 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL392158 | FALLYPRIDE | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL267723 | IOLOPRIDE | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL397103 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL397592 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL428561 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL8809 | RACLOPRIDE | Ki | = | 31.0 | nM | 7.51 |