Assay Detail
Binding
CHEMBL941853
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Displacement of [3H]8HO-DPAT from serotonin 5-HT1A receptor in pig striatal membrane
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
In vitro affinities of various halogenated benzamide derivatives as potential radioligands for non-invasive quantification of D(2)-like dopamine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.18 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL240106 | — | — | 1 | 6.85 |
| CHEMBL241169 | — | — | 1 | 6.82 |
| CHEMBL397103 | — | — | 1 | 6.77 |
| CHEMBL397592 | — | — | 1 | 6.64 |
| CHEMBL392158 | FALLYPRIDE | 3.0 | 1 | 5.96 |
| CHEMBL267723 | IOLOPRIDE | 2.0 | 1 | 5.96 |
| CHEMBL76402 | — | — | 1 | 5.66 |
| CHEMBL428561 | — | — | 1 | 5.64 |
| CHEMBL8809 | RACLOPRIDE | 2.0 | 1 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL240106 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL241169 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL397103 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL397592 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL392158 | FALLYPRIDE | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL267723 | IOLOPRIDE | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL76402 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL428561 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL8809 | RACLOPRIDE | Ki | = | 4400.0 | nM | 5.36 |