Assay Detail
Functional
CHEMBL941922
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against HeLa cells assessed as G2/M arrest by MTS assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Cyanopyridyl containing 1,4-dihydroindeno[1,2-c]pyrazoles as potent checkpoint kinase 1 inhibitors: improving oral biovailability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 21 | 4.99 | 5.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL248910 | — | — | 1 | 5.57 |
| CHEMBL248720 | — | — | 1 | 5.40 |
| CHEMBL248719 | — | — | 1 | 5.27 |
| CHEMBL398754 | — | — | 1 | 5.21 |
| CHEMBL249077 | — | — | 1 | 5.12 |
| CHEMBL249114 | — | — | 1 | 5.09 |
| CHEMBL249323 | — | — | 1 | 5.01 |
| CHEMBL398951 | — | — | 1 | 4.68 |
| CHEMBL400797 | — | — | 1 | 4.54 |
| CHEMBL249116 | — | — | 1 | 4.48 |
| CHEMBL249283 | — | — | 1 | 4.48 |
| CHEMBL248911 | — | — | 1 | - |
| CHEMBL245796 | — | — | 1 | - |
| CHEMBL249115 | — | — | 1 | - |
| CHEMBL400570 | — | — | 1 | - |
| CHEMBL249324 | — | — | 1 | - |
| CHEMBL251755 | — | — | 1 | - |
| CHEMBL249076 | — | — | 1 | - |
| CHEMBL249282 | — | — | 1 | - |
| CHEMBL401177 | — | — | 1 | - |
| CHEMBL398750 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL248910 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL248720 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL248719 | — | EC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL398754 | — | EC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL249077 | — | EC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL249114 | — | EC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL249323 | — | EC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL398951 | — | EC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL400797 | — | EC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL249116 | — | EC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL249283 | — | EC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL248911 | — | EC50 | > | 59000.0 | nM | - |
| CHEMBL245796 | — | EC50 | > | 59000.0 | nM | - |
| CHEMBL249115 | — | EC50 | > | 59000.0 | nM | - |
| CHEMBL400570 | — | EC50 | > | 59000.0 | nM | - |
| CHEMBL249324 | — | EC50 | > | 59000.0 | nM | - |
| CHEMBL251755 | — | EC50 | > | 59000.0 | nM | - |
| CHEMBL249076 | — | EC50 | > | 59000.0 | nM | - |
| CHEMBL249282 | — | EC50 | > | 59000.0 | nM | - |
| CHEMBL401177 | — | EC50 | > | 52000.0 | nM | - |
| CHEMBL398750 | — | EC50 | > | 59000.0 | nM | - |