Assay Detail
Binding
CHEMBL942096
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Inhibition of Chk2 kinase
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Serine/threonine-protein kinase Chk2 (CHEMBL2527) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of novel, selective and potent Chk2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.73 | 7.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL250230 | — | — | 1 | 7.06 |
| CHEMBL251256 | — | — | 1 | 6.85 |
| CHEMBL398561 | — | — | 1 | 6.66 |
| CHEMBL399237 | — | — | 1 | 6.52 |
| CHEMBL251284 | — | — | 1 | 6.51 |
| CHEMBL253115 | — | — | 1 | 6.38 |
| CHEMBL253116 | — | — | 1 | 6.34 |
| CHEMBL249251 | — | — | 1 | 6.34 |
| CHEMBL400772 | — | — | 1 | 6.33 |
| CHEMBL401105 | — | — | 1 | 6.05 |
| CHEMBL253324 | — | — | 1 | 6.00 |
| CHEMBL253542 | — | — | 1 | 5.92 |
| CHEMBL253541 | — | — | 1 | 5.75 |
| CHEMBL398759 | — | — | 1 | 5.64 |
| CHEMBL249253 | — | — | 1 | 5.30 |
| CHEMBL249252 | — | — | 1 | 5.10 |
| CHEMBL399151 | — | — | 1 | 4.96 |
| CHEMBL398758 | — | — | 1 | 4.96 |
| CHEMBL438150 | — | — | 1 | 4.77 |
| CHEMBL249255 | — | — | 1 | 4.72 |
| CHEMBL251629 | — | — | 1 | 4.72 |
| CHEMBL251628 | — | — | 1 | 4.43 |
| CHEMBL251471 | — | — | 1 | 4.40 |
| CHEMBL398760 | — | — | 1 | - |
| CHEMBL251473 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL250230 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL251256 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL398561 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL399237 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL251284 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL253115 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL253116 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL249251 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL400772 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL401105 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL253324 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL253542 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL253541 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL398759 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL249253 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL249252 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL399151 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL398758 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL438150 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL249255 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL251629 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL251628 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL251471 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL398760 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL251473 | — | IC50 | > | 40000.0 | nM | - |