Assay Detail
Binding
CHEMBL942218
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Inhibition of Hsp90 in human A2058 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A2058 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Dihydroxylphenyl amides as inhibitors of the Hsp90 molecular chaperone.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.74 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL383824 | ALVESPIMYCIN | 2.0 | 1 | 8.10 |
| CHEMBL486750 | — | — | 1 | 7.74 |
| CHEMBL486547 | — | — | 1 | 7.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL383824 | ALVESPIMYCIN | EC50 | = | 7.9 | nM | 8.10 |
| CHEMBL486750 | — | EC50 | = | 18.3 | nM | 7.74 |
| CHEMBL486547 | — | EC50 | = | 40.9 | nM | 7.39 |