Assay Detail
Binding
CHEMBL942267
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Inhibition of human recombinant NAT1 assessed as hydrolysis of acetyl coA using PABA as substrate by Ellman's method
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective small molecule inhibitors of the potential breast cancer marker, human arylamine N-acetyltransferase 1, and its murine homologue, mouse arylamine N-acetyltransferase 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.37 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL458614 | — | — | 1 | 6.48 |
| CHEMBL457919 | — | — | 1 | 6.22 |
| CHEMBL431550 | — | — | 1 | 5.96 |
| CHEMBL511165 | — | — | 1 | 5.96 |
| CHEMBL506606 | — | — | 1 | 5.47 |
| CHEMBL110470 | — | — | 1 | 5.44 |
| CHEMBL458705 | — | — | 1 | 5.41 |
| CHEMBL201467 | — | — | 1 | 5.33 |
| CHEMBL456849 | — | — | 1 | 5.12 |
| CHEMBL502693 | — | — | 1 | 5.09 |
| CHEMBL387624 | — | — | 1 | 4.89 |
| CHEMBL305763 | — | — | 1 | 4.89 |
| CHEMBL458999 | — | — | 1 | 4.77 |
| CHEMBL487697 | — | — | 1 | 4.77 |
| CHEMBL512033 | — | — | 1 | 4.75 |
| CHEMBL224521 | — | — | 1 | - |
| CHEMBL402427 | — | — | 1 | - |
| CHEMBL224172 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL458614 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL457919 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL431550 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL511165 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL506606 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL110470 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL458705 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL201467 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL456849 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL502693 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL387624 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL305763 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL458999 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL487697 | — | IC50 | = | 16900.0 | nM | 4.77 |
| CHEMBL512033 | — | IC50 | = | 17600.0 | nM | 4.75 |
| CHEMBL224521 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL402427 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL224172 | — | IC50 | > | 30000.0 | nM | - |