Assay Detail
Binding
CHEMBL942381
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of wild type PPAR-gamma-mediated transcriptional activity assessed as luciferase reporter activity
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Insights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.52 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL121 | ROSIGLITAZONE | 4.0 | 1 | 8.57 |
| CHEMBL479207 | — | — | 1 | 7.32 |
| CHEMBL477119 | — | — | 1 | 6.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL121 | ROSIGLITAZONE | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL479207 | — | EC50 | = | 47.7 | nM | 7.32 |
| CHEMBL477119 | — | EC50 | = | 208.0 | nM | 6.68 |