Assay Detail
Functional
CHEMBL942571
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Antimalarial activity against Plasmodium falciparum DD2 by [3H]hypoxanthine uptake
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Type II NADH dehydrogenase of the respiratory chain of Plasmodium falciparum and its inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.08 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1450 | ATOVAQUONE | 4.0 | 1 | 8.70 |
| CHEMBL275638 | FLAVONE | 2.0 | 1 | 8.70 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 8.00 |
| CHEMBL224182 | — | — | 1 | 6.62 |
| CHEMBL397686 | DIPHENYLENEIODONIUM CHLORIDE | — | 1 | 5.57 |
| CHEMBL481680 | DIPHENYLIODONIUM CHLORIDE | — | 1 | 4.91 |
| CHEMBL429023 | ROTENONE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1450 | ATOVAQUONE | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL275638 | FLAVONE | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL269671 | ARTEMISININ | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL224182 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL397686 | DIPHENYLENEIODONIUM CHLORIDE | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL481680 | DIPHENYLIODONIUM CHLORIDE | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL429023 | ROTENONE | IC50 | > | 10000.0 | nM | - |