Assay Detail
Binding
CHEMBL942694
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Inhibition of ROCK2
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Chroman-3-amides as potent Rho kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 8.07 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL519123 | — | — | 1 | 8.70 |
| CHEMBL482363 | — | — | 1 | 8.70 |
| CHEMBL455658 | — | — | 1 | 8.70 |
| CHEMBL474425 | — | — | 1 | 8.52 |
| CHEMBL480586 | — | — | 1 | 8.52 |
| CHEMBL519959 | — | — | 1 | 8.52 |
| CHEMBL475601 | — | — | 1 | 8.52 |
| CHEMBL520103 | — | — | 1 | 8.52 |
| CHEMBL482351 | — | — | 1 | 8.52 |
| CHEMBL519304 | — | — | 1 | 8.52 |
| CHEMBL519269 | — | — | 1 | 8.40 |
| CHEMBL475612 | — | — | 1 | 8.40 |
| CHEMBL480746 | — | — | 1 | 8.40 |
| CHEMBL519101 | — | — | 1 | 8.40 |
| CHEMBL480585 | — | — | 1 | 8.40 |
| CHEMBL481553 | — | — | 1 | 8.30 |
| CHEMBL475613 | — | — | 1 | 8.30 |
| CHEMBL481731 | — | — | 1 | 8.30 |
| CHEMBL482337 | — | — | 1 | 8.15 |
| CHEMBL481684 | — | — | 1 | 8.00 |
| CHEMBL482309 | — | — | 1 | 8.00 |
| CHEMBL481889 | — | — | 1 | 7.92 |
| CHEMBL514172 | — | — | 1 | 7.77 |
| CHEMBL442574 | — | — | 1 | 7.52 |
| CHEMBL482163 | — | — | 1 | 7.11 |
| CHEMBL482310 | — | — | 1 | 7.07 |
| CHEMBL481509 | — | — | 1 | 7.03 |
| CHEMBL474593 | — | — | 1 | 6.54 |
| CHEMBL474426 | — | — | 1 | 6.19 |
| CHEMBL481685 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL519123 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL455658 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL482363 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL519304 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL482351 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL520103 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL475601 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL519959 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL474425 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL480586 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL519269 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL475612 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL480746 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL519101 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL480585 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL475613 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL481731 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL481553 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL482337 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL481684 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL482309 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL481889 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL514172 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL442574 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL482163 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL482310 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL481509 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL474593 | — | IC50 | = | 285.0 | nM | 6.54 |
| CHEMBL474426 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL481685 | — | IC50 | < | 2.0 | nM | - |
| CHEMBL482336 | — | IC50 | < | 2.0 | nM | - |
| CHEMBL481545 | — | IC50 | < | 2.0 | nM | - |
| CHEMBL481735 | — | IC50 | < | 2.0 | nM | - |