Assay Detail
Binding
CHEMBL942697
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Inhibition of PKA
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Chroman-3-amides as potent Rho kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 6.11 | 7.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL480746 | — | — | 1 | 7.09 |
| CHEMBL519101 | — | — | 1 | 7.06 |
| CHEMBL480586 | — | — | 1 | 6.96 |
| CHEMBL481731 | — | — | 1 | 6.93 |
| CHEMBL455658 | — | — | 1 | 6.90 |
| CHEMBL481685 | — | — | 1 | 6.69 |
| CHEMBL475612 | — | — | 1 | 6.57 |
| CHEMBL480585 | — | — | 1 | 6.54 |
| CHEMBL482351 | — | — | 1 | 6.49 |
| CHEMBL475601 | — | — | 1 | 6.36 |
| CHEMBL514172 | — | — | 1 | 6.28 |
| CHEMBL520103 | — | — | 1 | 6.15 |
| CHEMBL482363 | — | — | 1 | 6.02 |
| CHEMBL519959 | — | — | 1 | 5.90 |
| CHEMBL519304 | — | — | 1 | 5.87 |
| CHEMBL474425 | — | — | 1 | 5.85 |
| CHEMBL482337 | — | — | 1 | 5.82 |
| CHEMBL481889 | — | — | 1 | 5.79 |
| CHEMBL482310 | — | — | 1 | 5.78 |
| CHEMBL519269 | — | — | 1 | 5.75 |
| CHEMBL482309 | — | — | 1 | 5.70 |
| CHEMBL481553 | — | — | 1 | 5.62 |
| CHEMBL482163 | — | — | 1 | 5.51 |
| CHEMBL474593 | — | — | 1 | 5.43 |
| CHEMBL481545 | — | — | 1 | 5.14 |
| CHEMBL442574 | — | — | 1 | 4.77 |
| CHEMBL481509 | — | — | 1 | - |
| CHEMBL481684 | — | — | 1 | - |
| CHEMBL482336 | — | — | 1 | - |
| CHEMBL475613 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL480746 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL519101 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL480586 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL481731 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL455658 | — | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL481685 | — | IC50 | = | 206.0 | nM | 6.69 |
| CHEMBL475612 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL480585 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL482351 | — | IC50 | = | 327.0 | nM | 6.49 |
| CHEMBL475601 | — | IC50 | = | 437.0 | nM | 6.36 |
| CHEMBL514172 | — | IC50 | = | 531.0 | nM | 6.28 |
| CHEMBL520103 | — | IC50 | = | 705.0 | nM | 6.15 |
| CHEMBL482363 | — | IC50 | = | 955.0 | nM | 6.02 |
| CHEMBL519959 | — | IC50 | = | 1259.0 | nM | 5.90 |
| CHEMBL519304 | — | IC50 | = | 1348.0 | nM | 5.87 |
| CHEMBL474425 | — | IC50 | = | 1416.0 | nM | 5.85 |
| CHEMBL482337 | — | IC50 | = | 1518.0 | nM | 5.82 |
| CHEMBL481889 | — | IC50 | = | 1628.0 | nM | 5.79 |
| CHEMBL482310 | — | IC50 | = | 1644.0 | nM | 5.78 |
| CHEMBL519269 | — | IC50 | = | 1764.0 | nM | 5.75 |
| CHEMBL482309 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL481553 | — | IC50 | = | 2390.0 | nM | 5.62 |
| CHEMBL482163 | — | IC50 | = | 3062.0 | nM | 5.51 |
| CHEMBL474593 | — | IC50 | = | 3734.0 | nM | 5.43 |
| CHEMBL481545 | — | IC50 | = | 7316.0 | nM | 5.14 |
| CHEMBL442574 | — | IC50 | = | 16850.0 | nM | 4.77 |
| CHEMBL481509 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL481684 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL482336 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL475613 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL474426 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL481735 | — | IC50 | > | 2000.0 | nM | - |