Assay Detail
Functional
CHEMBL942701
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human delta opioid receptor expressed in CHO cell membrane by [35S]GTP-gamma-S binding assay
18
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. 5. Opioid receptor binding properties of N-((4'-phenyl)-phenethyl) analogues of 8-CAC.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 8.29 | 9.17 |
| Emax | 9 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL249985 | — | — | 2 | 9.17 |
| CHEMBL438871 | — | — | 2 | 8.70 |
| CHEMBL377789 | — | — | 2 | 8.52 |
| CHEMBL13470 | SNC-80 | — | 2 | 8.32 |
| CHEMBL250993 | — | — | 2 | 7.85 |
| CHEMBL401278 | — | — | 2 | 7.75 |
| CHEMBL249567 | — | — | 2 | 7.70 |
| CHEMBL430397 | — | — | 2 | - |
| CHEMBL399465 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL249985 | — | EC50 | = | 0.68 | nM | 9.17 |
| CHEMBL438871 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL377789 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL13470 | SNC-80 | EC50 | = | 4.8 | nM | 8.32 |
| CHEMBL250993 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL401278 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL249567 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL377789 | — | Emax | = | 69.0 | % | - |
| CHEMBL13470 | SNC-80 | Emax | = | 120.0 | % | - |
| CHEMBL430397 | — | EC50 | - | — | - | |
| CHEMBL430397 | — | Emax | - | — | - | |
| CHEMBL438871 | — | Emax | = | 45.0 | % | - |
| CHEMBL250993 | — | Emax | = | 85.0 | % | - |
| CHEMBL249567 | — | Emax | = | 120.0 | % | - |
| CHEMBL399465 | — | EC50 | - | — | - | |
| CHEMBL399465 | — | Emax | - | — | - | |
| CHEMBL401278 | — | Emax | = | 43.0 | % | - |
| CHEMBL249985 | — | Emax | = | 70.0 | % | - |