Assay Detail
Functional
CHEMBL942710
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Cytotoxicity against HeLa cells by MTS assay
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Macrocyclic ureas as potent and selective Chk1 inhibitors: an improved synthesis, kinome profiling, structure-activity relationships, and preliminary pharmacokinetics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 35 | 4.91 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL248554 | — | — | 1 | 5.92 |
| CHEMBL400397 | — | — | 1 | 5.72 |
| CHEMBL401196 | — | — | 1 | 5.55 |
| CHEMBL248555 | — | — | 1 | 5.47 |
| CHEMBL249364 | — | — | 1 | 5.30 |
| CHEMBL249972 | — | — | 1 | 5.27 |
| CHEMBL249971 | — | — | 1 | 4.87 |
| CHEMBL400806 | — | — | 1 | 4.86 |
| CHEMBL248553 | — | — | 1 | 4.85 |
| CHEMBL249154 | — | — | 1 | 4.76 |
| CHEMBL400693 | — | — | 1 | 4.73 |
| CHEMBL248951 | — | — | 1 | 4.61 |
| CHEMBL437772 | — | — | 1 | 4.47 |
| CHEMBL399916 | — | — | 1 | 4.34 |
| CHEMBL400574 | — | — | 1 | 4.26 |
| CHEMBL375097 | — | — | 1 | 4.24 |
| CHEMBL248757 | — | — | 1 | 4.23 |
| CHEMBL249363 | — | — | 1 | - |
| CHEMBL248755 | — | — | 1 | - |
| CHEMBL249156 | — | — | 1 | - |
| CHEMBL249764 | — | — | 1 | - |
| CHEMBL249155 | — | — | 1 | - |
| CHEMBL249765 | — | — | 1 | - |
| CHEMBL400805 | — | — | 1 | - |
| CHEMBL398875 | — | — | 1 | - |
| CHEMBL248953 | — | — | 1 | - |
| CHEMBL250173 | — | — | 1 | - |
| CHEMBL400668 | — | — | 1 | - |
| CHEMBL250375 | — | — | 1 | - |
| CHEMBL248952 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL248554 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL400397 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL401196 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL248555 | — | EC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL249364 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL249972 | — | EC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL249971 | — | EC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL400806 | — | EC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL248553 | — | EC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL249154 | — | EC50 | = | 17400.0 | nM | 4.76 |
| CHEMBL400693 | — | EC50 | = | 18700.0 | nM | 4.73 |
| CHEMBL248951 | — | EC50 | = | 24300.0 | nM | 4.61 |
| CHEMBL437772 | — | EC50 | = | 34100.0 | nM | 4.47 |
| CHEMBL399916 | — | EC50 | = | 45700.0 | nM | 4.34 |
| CHEMBL400574 | — | EC50 | = | 54500.0 | nM | 4.26 |
| CHEMBL375097 | — | EC50 | = | 57600.0 | nM | 4.24 |
| CHEMBL248757 | — | EC50 | = | 59300.0 | nM | 4.23 |
| CHEMBL248756 | — | EC50 | > | 59300.0 | nM | - |
| CHEMBL400575 | — | EC50 | > | 59300.0 | nM | - |
| CHEMBL400804 | — | EC50 | > | 59300.0 | nM | - |
| CHEMBL398757 | — | EC50 | > | 59300.0 | nM | - |
| CHEMBL401337 | — | EC50 | > | 59300.0 | nM | - |
| CHEMBL248952 | — | EC50 | > | 59300.0 | nM | - |
| CHEMBL250375 | — | EC50 | > | 59300.0 | nM | - |
| CHEMBL400668 | — | EC50 | > | 59300.0 | nM | - |
| CHEMBL250173 | — | EC50 | > | 59300.0 | nM | - |
| CHEMBL248953 | — | EC50 | > | 59300.0 | nM | - |
| CHEMBL398875 | — | EC50 | > | 59300.0 | nM | - |
| CHEMBL400805 | — | EC50 | > | 59300.0 | nM | - |
| CHEMBL249765 | — | EC50 | > | 59300.0 | nM | - |
| CHEMBL249155 | — | EC50 | > | 59300.0 | nM | - |
| CHEMBL249764 | — | EC50 | > | 59300.0 | nM | - |
| CHEMBL249156 | — | EC50 | > | 59300.0 | nM | - |
| CHEMBL248755 | — | EC50 | > | 59300.0 | nM | - |
| CHEMBL249363 | — | EC50 | > | 59300.0 | nM | - |