Assay Detail
Binding
CHEMBL943257
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Displacement of [3H]Ro15-1788 from benzodiazepine binding site of GABAA alpha1 T162C beta-2-gamma-2 receptor mutant expressed in HEK293T cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK-293T |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structural requirements for eszopiclone and zolpidem binding to the gamma-aminobutyric acid type-A (GABAA) receptor are different.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.70 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL407 | FLUMAZENIL | 4.0 | 1 | 8.66 |
| CHEMBL1522 | ESZOPICLONE | 4.0 | 1 | 7.47 |
| CHEMBL911 | ZOLPIDEM | 4.0 | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL407 | FLUMAZENIL | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL1522 | ESZOPICLONE | Ki | = | 33.8 | nM | 7.47 |
| CHEMBL911 | ZOLPIDEM | Ki | = | 109.0 | nM | 6.96 |