Assay Detail
Functional
CHEMBL943361
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Antiangiogenic activity against HUVEC assessed as inhibition of capillary-like structure formation by NCI antiangiogenesis assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HUVEC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of dihydroartemisinin and dihydroartemisitene acetal dimers showing anticancer and antiprotozoal activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.31 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.30 |
| CHEMBL424278 | O-CHLOROACETYLCARBAMOYLFUMAGILLOL | 2.0 | 1 | 6.00 |
| CHEMBL505741 | — | — | 1 | 4.51 |
| CHEMBL446833 | — | — | 1 | 4.41 |
| CHEMBL443598 | — | — | 1 | 4.34 |
| CHEMBL445526 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL424278 | O-CHLOROACETYLCARBAMOYLFUMAGILLOL | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL505741 | — | IC50 | = | 30800.0 | nM | 4.51 |
| CHEMBL446833 | — | IC50 | = | 38800.0 | nM | 4.41 |
| CHEMBL443598 | — | IC50 | = | 45800.0 | nM | 4.34 |
| CHEMBL445526 | — | IC50 | > | 50000.0 | nM | - |