Assay Detail
Binding
CHEMBL943653
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Inhibition of MRCKalpha
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Serine/threonine-protein kinase MRCK alpha (CHEMBL4516) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Chroman-3-amides as potent Rho kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.87 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL481545 | — | — | 1 | 7.10 |
| CHEMBL482336 | — | — | 1 | 6.82 |
| CHEMBL474425 | — | — | 1 | 6.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL481545 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL482336 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL474425 | — | IC50 | = | 210.0 | nM | 6.68 |