Assay Detail
Functional
CHEMBL943947
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Antimalarial activity against Plasmodium falciparum 3D7
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure-activity relationships of C6-uridine derivatives targeting plasmodia orotidine monophosphate decarboxylase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.75 | 5.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL220442 | — | — | 1 | 5.21 |
| CHEMBL255062 | — | — | 1 | 4.54 |
| CHEMBL401482 | — | — | 1 | 4.50 |
| CHEMBL439055 | — | — | 1 | - |
| CHEMBL255061 | — | — | 1 | - |
| CHEMBL399850 | — | — | 1 | - |
| CHEMBL267051 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL220442 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL255062 | — | IC50 | = | 28500.0 | nM | 4.54 |
| CHEMBL401482 | — | IC50 | = | 31700.0 | nM | 4.50 |
| CHEMBL439055 | — | IC50 | = | 530500.0 | nM | - |
| CHEMBL255061 | — | IC50 | > | 1500000.0 | nM | - |
| CHEMBL399850 | — | IC50 | = | 1226000.0 | nM | - |
| CHEMBL267051 | — | IC50 | = | 446000.0 | nM | - |