Assay Detail
Functional
CHEMBL944029
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at PPARalpha expressed in HEK293 cells by GAL4 transactivation assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Peroxisome proliferator-activated receptor alpha (CHEMBL239) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and synthesis of indane-ureido-thioisobutyric acids: A novel class of PPARalpha agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 6.56 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL249865 | — | — | 1 | 6.77 |
| CHEMBL278590 | GSK-9578 | — | 1 | 6.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL249865 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL278590 | GSK-9578 | EC50 | = | 450.0 | nM | 6.35 |