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Assay Detail

CHEMBL944035

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Binding
Inhibition of MMP2
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

72 kDa type IV collagenase (CHEMBL333)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

A novel series of highly selective inhibitors of MMP-3.
Whitlock GA, Dack KN, Dickinson RP, Lewis ML.
Bioorg Med Chem Lett (2007) 17 : 6750 -6753
PubMed 18029177 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 6.35 8.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL254398 1 8.05
CHEMBL254604 1 7.77
CHEMBL398640 1 6.76
CHEMBL251918 1 6.73
CHEMBL400083 1 6.71
CHEMBL255030 1 6.71
CHEMBL254817 1 6.65
CHEMBL398641 1 6.58
CHEMBL254606 1 6.50
CHEMBL442445 1 6.34
CHEMBL251917 1 6.28
CHEMBL252117 1 6.27
CHEMBL254605 1 6.21
CHEMBL428767 1 6.11
CHEMBL251916 1 6.07
CHEMBL255029 1 6.00
CHEMBL254818 1 5.92
CHEMBL254816 1 5.51
CHEMBL398639 1 5.36
CHEMBL250266 1 4.47

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL254398 IC50 = 9.0 nM 8.05
CHEMBL254604 IC50 = 17.0 nM 7.77
CHEMBL398640 IC50 = 173.0 nM 6.76
CHEMBL251918 IC50 = 188.0 nM 6.73
CHEMBL400083 IC50 = 196.0 nM 6.71
CHEMBL255030 IC50 = 196.0 nM 6.71
CHEMBL254817 IC50 = 222.0 nM 6.65
CHEMBL398641 IC50 = 262.0 nM 6.58
CHEMBL254606 IC50 = 320.0 nM 6.50
CHEMBL442445 IC50 = 457.0 nM 6.34
CHEMBL251917 IC50 = 529.0 nM 6.28
CHEMBL252117 IC50 = 534.0 nM 6.27
CHEMBL254605 IC50 = 620.0 nM 6.21
CHEMBL428767 IC50 = 776.0 nM 6.11
CHEMBL251916 IC50 = 853.0 nM 6.07
CHEMBL255029 IC50 = 998.0 nM 6.00
CHEMBL254818 IC50 = 1208.0 nM 5.92
CHEMBL254816 IC50 = 3080.0 nM 5.51
CHEMBL398639 IC50 = 4380.0 nM 5.36
CHEMBL250266 IC50 = 34200.0 nM 4.47