Assay Detail

CHEMBL944150

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Reduction of dopamine level in catecholamine-inducing rat PC12 cells

ChEMBL ↗

Free Research Context This assay will appear in recent viewed items on this browser. Open the demo workspace to preview project-only review queues.

Research home Demo workspace

Target

PC-12 (CHEMBL612556) ↗

Open DB target context

Use one target anchor to keep assay intent, target linkage, and tested compound review aligned.

Loading context

PC-12 (CHEMBL612556) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target PC-12

CHEMBL612556

Anchored from Assay target.

Protein identity PC-12

Disease frame Disease evidence pending

Open the live target snapshot or evidence card before reviewing assay metadata so target fit and disease framing stay reusable.

Review focus Open DB context pending

Open the live target snapshot before relying on this target frame across surface handoff.

Open target snapshot Open evidence card Search with this context

Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Rattus norvegicus
Cell Type	PC-12
Confidence	1 — Organism
Curated By	Autocuration

Target

PC-12 (CHEMBL612556) ↗

Type	CELL-LINE
Organism	Rattus norvegicus

Publication

Advances in development of dopaminergic aporphinoids.

Zhang A, Zhang Y, Branfman AR, Baldessarini RJ, Neumeyer JL.
J Med Chem (2007) 50 : 171 -181
PubMed 17228858 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	4.57	4.57

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL157912	(S)-BULBOCAPNINE	—	1	4.57

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL157912	(S)-BULBOCAPNINE	IC50	=	27000.0	nM	4.57