Assay Detail
Binding
CHEMBL944157
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Inhibition of tyrosine hydroxylase
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Advances in development of dopaminergic aporphinoids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.24 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL225230 | R-N-PROPYLNORAPOMORPHINE | — | 1 | 6.52 |
| CHEMBL330274 | — | — | 1 | 6.00 |
| CHEMBL27559 | — | — | 1 | 4.38 |
| CHEMBL283489 | — | — | 1 | 4.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL225230 | R-N-PROPYLNORAPOMORPHINE | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL330274 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL27559 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL283489 | — | IC50 | = | 87000.0 | nM | 4.06 |