Assay Detail
Binding
CHEMBL944174
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Inhibition of COX2
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Structural and functional basis of cyclooxygenase inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.50 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL404108 | LUMIRACOXIB | 4.0 | 1 | 8.15 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 8.00 |
| CHEMBL563 | FLURBIPROFEN | 4.0 | 1 | 8.00 |
| CHEMBL139 | DICLOFENAC | 4.0 | 1 | 7.70 |
| CHEMBL95643 | — | — | 1 | 7.30 |
| CHEMBL404107 | — | — | 1 | 7.30 |
| CHEMBL254377 | — | — | 1 | 7.30 |
| CHEMBL95311 | — | — | 1 | 7.22 |
| CHEMBL442441 | — | — | 1 | 7.00 |
| CHEMBL257539 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL404108 | LUMIRACOXIB | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL563 | FLURBIPROFEN | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL139 | DICLOFENAC | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL95643 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL404107 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL254377 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL95311 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL442441 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL257539 | — | IC50 | = | 100.0 | nM | 7.00 |