Assay Detail
Binding
CHEMBL944207
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Inhibition of Chk1
75
Total Activities
75
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Serine/threonine-protein kinase Chk1 (CHEMBL4630) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a novel class of 2-ureido thiophene carboxamide checkpoint kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 75 | 7.12 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL519913 | — | — | 1 | 8.52 |
| CHEMBL471096 | — | — | 1 | 8.52 |
| CHEMBL488231 | — | — | 1 | 8.40 |
| CHEMBL519248 | — | — | 1 | 8.30 |
| CHEMBL470289 | — | — | 1 | 8.30 |
| CHEMBL469481 | — | — | 1 | 8.22 |
| CHEMBL520902 | — | — | 1 | 8.22 |
| CHEMBL520734 | — | — | 1 | 8.22 |
| CHEMBL488230 | — | — | 1 | 8.22 |
| CHEMBL488044 | — | — | 1 | 8.15 |
| CHEMBL487273 | — | — | 1 | 8.15 |
| CHEMBL459428 | — | — | 1 | 8.15 |
| CHEMBL504542 | — | — | 1 | 8.10 |
| CHEMBL459631 | — | — | 1 | 8.05 |
| CHEMBL516784 | — | — | 1 | 8.05 |
| CHEMBL527881 | — | — | 1 | 8.05 |
| CHEMBL487622 | — | — | 1 | 8.05 |
| CHEMBL471549 | — | — | 1 | 8.00 |
| CHEMBL513191 | — | — | 1 | 8.00 |
| CHEMBL488835 | — | — | 1 | 8.00 |
| CHEMBL518661 | — | — | 1 | 8.00 |
| CHEMBL470288 | — | — | 1 | 8.00 |
| CHEMBL486234 | — | — | 1 | 7.96 |
| CHEMBL517553 | — | — | 1 | 7.96 |
| CHEMBL487437 | — | — | 1 | 7.89 |
| CHEMBL513377 | — | — | 1 | 7.85 |
| CHEMBL460685 | — | — | 1 | 7.77 |
| CHEMBL469686 | — | — | 1 | 7.72 |
| CHEMBL510101 | — | — | 1 | 7.54 |
| CHEMBL508982 | — | — | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL519913 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL471096 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL488231 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL519248 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL470289 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL469481 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL520902 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL520734 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL488230 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL488044 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL487273 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL459428 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL504542 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL527881 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL516784 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL459631 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL487622 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL471549 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL513191 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL488835 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL518661 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL470288 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL486234 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL517553 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL487437 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL513377 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL460685 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL469686 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL510101 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL508982 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL452274 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL461294 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL507700 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL453053 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL488039 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL516478 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL488287 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL452020 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL452273 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL471094 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL471095 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL459650 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL460888 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL460889 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL488239 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL459651 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL471365 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL471548 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL452021 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL486233 | — | IC50 | = | 160.0 | nM | 6.80 |