Assay Detail
Binding
CHEMBL944208
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Inhibition of Cdk1
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 2-associated protein 1 (CHEMBL5578) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a novel class of 2-ureido thiophene carboxamide checkpoint kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 5.24 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL488231 | — | — | 1 | 5.75 |
| CHEMBL520902 | — | — | 1 | 5.66 |
| CHEMBL516784 | — | — | 1 | 5.48 |
| CHEMBL488230 | — | — | 1 | 5.48 |
| CHEMBL518777 | — | — | 1 | 5.44 |
| CHEMBL469481 | — | — | 1 | 5.44 |
| CHEMBL470288 | — | — | 1 | 5.43 |
| CHEMBL527881 | — | — | 1 | 5.43 |
| CHEMBL518661 | — | — | 1 | 5.32 |
| CHEMBL487273 | — | — | 1 | 5.29 |
| CHEMBL520734 | — | — | 1 | 5.28 |
| CHEMBL469686 | — | — | 1 | 5.27 |
| CHEMBL513191 | — | — | 1 | 5.26 |
| CHEMBL519913 | — | — | 1 | 5.25 |
| CHEMBL517553 | — | — | 1 | 5.25 |
| CHEMBL488287 | — | — | 1 | 5.08 |
| CHEMBL513377 | — | — | 1 | 5.06 |
| CHEMBL459428 | — | — | 1 | 4.99 |
| CHEMBL486234 | — | — | 1 | 4.97 |
| CHEMBL471549 | — | — | 1 | 4.57 |
| CHEMBL460888 | — | — | 1 | 4.36 |
| CHEMBL460889 | — | — | 1 | - |
| CHEMBL461294 | — | — | 1 | - |
| CHEMBL452020 | — | — | 1 | - |
| CHEMBL459631 | — | — | 1 | - |
| CHEMBL488835 | — | — | 1 | - |
| CHEMBL487622 | — | — | 1 | - |
| CHEMBL519248 | — | — | 1 | - |
| CHEMBL470289 | — | — | 1 | - |
| CHEMBL488044 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL488231 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL520902 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL516784 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL488230 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL518777 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL469481 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL470288 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL527881 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL518661 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL487273 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL520734 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL469686 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL513191 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL519913 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL517553 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL488287 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL513377 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL459428 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL486234 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL471549 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL460888 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL460889 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL461294 | — | IC50 | > | 69000.0 | nM | - |
| CHEMBL452020 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL459631 | — | IC50 | - | — | - | |
| CHEMBL488835 | — | IC50 | - | — | - | |
| CHEMBL487622 | — | IC50 | - | — | - | |
| CHEMBL519248 | — | IC50 | - | — | - | |
| CHEMBL470289 | — | IC50 | - | — | - | |
| CHEMBL488044 | — | IC50 | - | — | - | |
| CHEMBL488039 | — | IC50 | - | — | - | |
| CHEMBL504542 | — | IC50 | - | — | - | |
| CHEMBL487437 | — | IC50 | - | — | - |