Assay Detail
Functional
CHEMBL944209
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Abrogation of camptothecin induced cell cycle arrest at G2/M phase in human HT29 cells
58
Total Activities
58
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a novel class of 2-ureido thiophene carboxamide checkpoint kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 58 | 6.43 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL518661 | — | — | 1 | 7.77 |
| CHEMBL487273 | — | — | 1 | 7.70 |
| CHEMBL517553 | — | — | 1 | 7.70 |
| CHEMBL516784 | — | — | 1 | 7.52 |
| CHEMBL513377 | — | — | 1 | 7.40 |
| CHEMBL470288 | — | — | 1 | 7.40 |
| CHEMBL488044 | — | — | 1 | 7.22 |
| CHEMBL513191 | — | — | 1 | 7.16 |
| CHEMBL459631 | — | — | 1 | 7.10 |
| CHEMBL469481 | — | — | 1 | 7.10 |
| CHEMBL488287 | — | — | 1 | 7.05 |
| CHEMBL471096 | — | — | 1 | 6.96 |
| CHEMBL486234 | — | — | 1 | 6.89 |
| CHEMBL469686 | — | — | 1 | 6.77 |
| CHEMBL520902 | — | — | 1 | 6.70 |
| CHEMBL507700 | — | — | 1 | 6.57 |
| CHEMBL488230 | — | — | 1 | 6.52 |
| CHEMBL527881 | — | — | 1 | 6.50 |
| CHEMBL488231 | — | — | 1 | 6.47 |
| CHEMBL459650 | — | — | 1 | 6.24 |
| CHEMBL488835 | — | — | 1 | 6.21 |
| CHEMBL487437 | — | — | 1 | 6.04 |
| CHEMBL508982 | — | — | 1 | 6.02 |
| CHEMBL518777 | — | — | 1 | 5.96 |
| CHEMBL459428 | — | — | 1 | 5.92 |
| CHEMBL504542 | — | — | 1 | 5.75 |
| CHEMBL519226 | — | — | 1 | 5.72 |
| CHEMBL471094 | — | — | 1 | 5.68 |
| CHEMBL488039 | — | — | 1 | 5.66 |
| CHEMBL486233 | — | — | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL518661 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL487273 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL517553 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL516784 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL513377 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL470288 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL488044 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL513191 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL459631 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL469481 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL488287 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL471096 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL486234 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL469686 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL520902 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL507700 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL488230 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL527881 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL488231 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL459650 | — | EC50 | = | 580.0 | nM | 6.24 |
| CHEMBL488835 | — | EC50 | = | 610.0 | nM | 6.21 |
| CHEMBL487437 | — | EC50 | = | 920.0 | nM | 6.04 |
| CHEMBL508982 | — | EC50 | = | 960.0 | nM | 6.02 |
| CHEMBL518777 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL459428 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL504542 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL519226 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL471094 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL488039 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL486233 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL471549 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL519248 | — | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL459651 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL487622 | — | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL471095 | — | EC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL470289 | — | EC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL459442 | — | EC50 | - | — | - | |
| CHEMBL516615 | — | EC50 | - | — | - | |
| CHEMBL461914 | — | EC50 | - | — | - | |
| CHEMBL512706 | — | EC50 | - | — | - | |
| CHEMBL520734 | — | EC50 | < | 9.0 | nM | - |
| CHEMBL471548 | — | EC50 | - | — | - | |
| CHEMBL488238 | — | EC50 | - | — | - | |
| CHEMBL452020 | — | EC50 | > | 12500.0 | nM | - |
| CHEMBL460889 | — | EC50 | > | 12500.0 | nM | - |
| CHEMBL460888 | — | EC50 | > | 12500.0 | nM | - |
| CHEMBL511138 | — | EC50 | > | 13000.0 | nM | - |
| CHEMBL519913 | — | EC50 | < | 8.0 | nM | - |
| CHEMBL452021 | — | EC50 | > | 12500.0 | nM | - |
| CHEMBL461294 | — | EC50 | > | 12500.0 | nM | - |